Thermo Fisher Scientific Cortactin Polyclonal Antibody
Rabbit polyclonal antibody targeting human cortactin for WB and IP applications. Recognizes residues 250–300 of cortactin. Unconjugated, liquid form, 0.20 mg/mL concentration. Stored at 4°C; shipped on wet ice. For research use only.
- 카탈로그번호
- A302607A
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 250 and 300 of human cortactin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Chicken
Target Information
Cortactin (Cttn) is a ubiquitous actin-binding protein originally identified as a substrate for Src. It contributes to actin cytoskeleton organization and cell shape, playing a role in lamellipodia formation and cell migration. Cortactin accumulates in actin-enriched peripheral structures, facilitating actin network formation.
It contains four major domains:
- N-terminal acidic (NTA) domain
- Tandem repeats domain
- C-terminal proline-rich domain
- SH3 domain
NTA associates with the Arp2/3 and WASP complex at F-actin branches. Cortactin promotes cell motility and invasion, including a critical role in invadopodia, actin-rich protrusions involved in ECM degradation by cancer cells. It is phosphorylated by Src family kinases at Y421, Y466, and Y482, and by Erk family kinases at S405 and S418.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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