Thermo Fisher Scientific CCL19 Monoclonal Antibody (OTI6A3), TrueMAB
인간 CCL19 단백질을 인식하는 마우스 단클론 항체로 Western blot에 적합합니다. 정제된 IgG1 항체로 PBS/BSA/glycerol 완충액에 보관됩니다. CCL19 및 CCL21 관련 연구와 면역세포 이동 메커니즘 분석에 활용 가능합니다.
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Applications
- Western Blot (WB): 1:2,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6A3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 22–98 of human CCL19 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CCL19, also known as MIP-3 beta (Macrophage Inflammatory Protein 3 beta), is a member of the CC-subfamily of chemokines. It is closely related to CCL21, sharing 32% amino acid sequence homology. CCL19 and CCL21 are mainly expressed by stromal cells in T cell-rich zones of lymph nodes and play critical roles in the homeostatic trafficking of naïve T cells and activated dendritic cells into secondary lymphoid organs. They also contribute to T cell priming, activation, and lymphocyte recruitment to inflamed tissues. Both signal through the G protein-coupled receptor CCR7, expressed on T cells and mature dendritic cells. Although both ligands bind CCR7 with the same affinity, only CCL19 binding induces receptor desensitization and internalization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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