Thermo Fisher Scientific Phospho-Histone H2A.X (Tyr142) Polyclonal Antibody
Phospho-Histone H2A.X (Tyr142) 폴리클로날 항체로, 인산화된 히스톤 H2A.X의 Tyr142 부위를 특이적으로 인식합니다. Western blot에 최적화되어 있으며, 인간, 마우스, 랫트 반응성이 확인되었습니다. 고순도 항원 친화 크로마토그래피 정제 항체로 연구용에 적합합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 142 (A-S-Q-E-Y(p)) derived from Human Histone H2A.X |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609377 |
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
Target Information
Histone H2A.X (H2AX) is a member of the histone H2A family, one of the four core histones forming the nucleosome core particle. In eukaryotes, DNA double-strand breaks (DSBs) trigger phosphorylation of serine 139 at the carboxy terminus of H2AX, resulting in gamma-H2AX. This phosphorylation can be detected by Western blotting or immunofluorescence to assess DSB frequency.
Phosphatidylinositol 3-kinases are implicated in H2AX phosphorylation, though the primary kinase (ATM, DNA-PK, ATR) remains under investigation. Structurally, H2A.X consists of 143 amino acids and is synthesized in both G1 and S-phase. Its mRNA exists in two forms: a 1600-base polyA-containing basal type and a 575-base replication type lacking polyA.
Histone H2A.X maps to the 11q23.2–q23.3 region of the human chromosome. It contributes to chromatin structure and regulates DNA repair protein MDC1 binding to DNA damage sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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