Thermo Fisher Scientific MDM2 Recombinant Mouse Monoclonal Antibody (rMDM2/9214)
Recombinant mouse monoclonal antibody targeting MDM2, validated for IHC (paraffin). Recognizes human MDM2 protein; suitable for studying p53 regulation and tumor biology. Supplied as liquid form, 200 µg/mL, stored at 4°C.
- 카탈로그번호
- 4193-MSM19-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific MDM2 Recombinant Mouse Monoclonal Antibody (rMDM2/9214)
Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | rMDM2/9214 |
| Immunogen | Recombinant human MDM2 protein fragment (exact sequence is proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Human liposarcoma
- Cellular Location: Nucleus
Target Information
MDM2 is a ubiquitin ligase for p53 and plays a central role in regulating p53 stability. It is located on chromosome 12q and is phosphorylated by Akt at Ser166 and Ser186, enhancing its interaction with p300 and promoting p53 ubiquitination and degradation. Phosphorylation also prevents MDM2 from binding to p19ARF, further increasing p53 degradation. Overexpression of MDM2 leads to p53 inactivation and reduced tumor suppressor function. MDM2 also interacts with proteins such as retinoblastoma 1 and ribosomal protein L5, influencing apoptosis, cell cycle, and tumorigenesis. It is overexpressed in various human malignancies, including soft tissue carcinomas and breast cancer. More than 40 alternatively spliced transcript variants have been identified in tumor and normal tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.