Thermo Fisher Scientific RNF111 Polyclonal Antibody
RNF111 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 및 ICC/IF 실험에 적합. 항원 친화 크로마토그래피로 정제되었으며, 0.2 mg/mL 농도의 액상 형태로 제공. 인간 RNF111 단백질에 특이적이며, 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human RNF111 (amino acids 13–115, UniProt ID: Q6ZNA4-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2646615 |
Product Specific Information
Immunogen sequence:
TLKVDMKSEI PSDAPKTQES LKGILLHPEP IGAAKSFPAG VEMINSKVGN EFSHLCDDSQ KQEKEMNGNQ QEQEKSLVVR KKRKSQQAGP SYVQNCVKEN QGI
- Highest antigen sequence identity to orthologs:
- Mouse: 85%
- Rat: 85%
Target Information
The RNF111 gene encodes a nuclear RING-domain containing E3 ubiquitin ligase. It interacts with the TGF-beta/NODAL signaling pathway by promoting ubiquitination and proteosomal degradation of negative regulators such as SMAD proteins, thereby enhancing TGF-beta target gene transcription. As a modulator of the nodal signaling cascade, RNF111 plays a critical role in mesoderm induction during embryonic development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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