Thermo Fisher Scientific Hrk Polyclonal Antibody
Human, Mouse, Rat 반응성을 가진 Rabbit Polyclonal HRK 항체로, IHC, ICC/IF, ELISA 등 다양한 응용에 사용 가능. KLH 접합 합성 펩타이드(aa 1-50)를 면역원으로 제작되었으며, 고순도 Protein A 정제. 연구용으로만 사용.
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Thermo Fisher Scientific Hrk Polyclonal Antibody
Applications 및 희석 배수
| 응용 분야 | 희석 배수 |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Activator of apoptosis harakiri, amino acids 1–50 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage conditions | −20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells.
Hrk, a pro-apoptotic member of the Bcl-2 homology domain-3 (BH3)-only group of the Bcl-2 family of proteins, was identified as a novel protein induced during programmed neuronal death.
It lacks significant homology to other Bcl-2 family members except for an 8-amino acid region similar to the BH3 motif of Bik.
Hrk regulates apoptosis through interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL via this domain.
It does not interact with the pro-apoptotic proteins Bax, Bak, or Bcl-XS.
Hrk localizes to mitochondrial membranes in a pattern similar to that previously reported for Bcl-2 and Bcl-XL.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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