Thermo Fisher Scientific HLA-DR/DP/DQ Monoclonal Antibody (CR3/43)

Thermo Fisher Scientific HLA-DR/DP/DQ Monoclonal Antibody (CR3/43)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• For immunocytochemistry, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE cell sections.

Target Information

MHC class II molecules are transmembrane glycoproteins composed of an alpha chain (36 kDa) and a beta chain (27 kDa). They are expressed primarily on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes.
Three loci—DR, DQ, and DP—encode the major expressed products of the human class II region.
Human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells, playing a critical role in the initiation of immune responses.

HLA and MHC antibodies are crucial in immunopeptidomics, aiding the identification and characterization of neoantigens via high-performance liquid chromatography coupled to tandem mass spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.