Thermo Fisher Scientific IDH1 Monoclonal Antibody (OTI3G9)
IDH1 단백질의 R132H 변이 영역을 인식하는 mouse monoclonal antibody로, WB 및 IHC(P)에서 검증됨. Human, Mouse, Rat, Dog 반응성. 고순도 affinity chromatography 정제, 안정적인 PBS/BSA/glycerol buffer 저장.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3G9 |
| Immunogen | Synthetic peptide around the R132H mutation region of the human IDH conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723259 |
Target Information
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one utilizing NAD(+) and the other NADP(+).
Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent forms localized to the mitochondrial matrix, and two NADP(+)-dependent forms—one mitochondrial and one cytosolic.
Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes, containing a PTS-1 peroxisomal targeting signal sequence.
This enzyme contributes to NADPH regeneration within peroxisomes and cytoplasmic NADPH production, supporting various reduction and hydroxylation reactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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