Thermo Fisher Scientific Phospho-GATA3 (Ser308) Polyclonal Antibody
Phospho-GATA3 (Ser308) 폴리클로날 항체로, 인산화된 GATA3 단백질 검출에 적합합니다. Rabbit IgG 기반으로 제작되었으며, ICC/IF 실험에서 사용 가능합니다. 1 mg/mL 농도의 액상 제품으로 -20°C에서 보관하며 연구용으로만 사용됩니다.
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Thermo Fisher Scientific Phospho-GATA3 (Ser308) Polyclonal Antibody
Applications and Tested Dilution
- Immunocytochemistry (ICC/IF): 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human GATA3 around the phosphorylation site of Ser308 (R-L-SP-A-A) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555092 |
Target Information
The genes for all four subunits of the T-cell antigen receptor (alpha, beta, gamma, and delta) are controlled by distinct enhancers and their enhancer-binding proteins. Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all four TCR genes.
GATA3, previously shown in chicken to be an enhancer-binding protein containing a zinc finger domain, is expressed abundantly in the T-lymphocyte lineage and participates in T-cell receptor gene activation through enhancer binding.
Labastie et al. (1994) cloned the human gene and the 5-prime end of the mouse gene. The human gene comprises six exons over 17 kb of DNA. Its two zinc fingers are encoded by two separate exons highly conserved with those of GATA1, though no other structural homologies were found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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