Thermo Fisher Scientific SASS6 Polyclonal Antibody
Human SASS6 단백질에 특이적인 Rabbit Polyclonal Antibody로, IHC(P) 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼(40% 글리세롤, 0.02% sodium azide) 용액 형태로 제공. 단기 4°C, 장기 -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SASS6. Recombinant protein control fragment (Product # RP-94349) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2646961 |
Product Specific Information
Immunogen sequence:
QKEQKELQDV GQSLRIKEQE VCKLQEQLEA TVKKLEESKQ LLKNNEKLIT WLNKELNENQ LVRKQDVLGP STTPPAHSSS NTIRSGISPN L
Sequence identity with orthologs:
- Mouse: 83%
- Rat: 82%
Target Information
Metadherin (Metastasis adhesion protein), also known as MTDH or LYRIC, is a protein localized with tight junction proteins ZO-1 and occludin in polarized epithelial cells. It is recruited during the maturation of the tight junction complex rather than serving as a structural component. Metadherin is overexpressed in breast cancer tissues and xenografts, while expressed at low levels in normal breast tissue. It binds to lung vasculature, a common site of breast cancer metastasis. Blocking its lung-homing domain or inhibiting metadherin expression has been reported to suppress metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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