Thermo Fisher Scientific Human NUP160 Synthetic Peptide

Thermo Fisher Scientific Human NUP160 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 14 amino acids near the carboxy terminus of human NUP160.
PEP-0685 can be used as a blocking peptide with polyclonal antibody PA5-20565.

Target Information

The nuclear pore complex (NPC) is a protein assembly localized at the nuclear rim and mediates macromolecular transport between the nucleus and the cytoplasm.
The mammalian nucleoporin (NUP)-160 is part of the hetero-oligomeric complex that also contains NUP107, NUP133, NUP96, and mammalian homolog of yeast sec13p.
While most of the NUP107-160 nuclear pore sub-complex localizes to the nuclear pore, a small fraction is observed at kinetochores and pro-metaphase spindle poles in mitotic cells in association with proteins such as Mad1, Mad2, Bub3, and Cdc20.
Immunodepletion of the NUP107-160 complex results in defective spindle assembly, indicating multiple functions.
NUP160 has been identified as an HIV dependency factor (HDF), suggesting potential as a drug target in HIV treatment.
Multiple isoforms of NUP160 are known to exist.

Usage Notice

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.