Thermo Fisher Scientific AOX1 Polyclonal Antibody
Human AOX1 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:200~1:500 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. ALS 관련 연구 등 AOX1 기능 분석에 적합.
- 카탈로그번호
- PA559107
- 판매단위
- pk
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human AOX1. Recombinant protein control fragment (Product #RP-96096). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2638039 |
Product Specific Information
Immunogen sequence:
GVVDIMTAEH LSDVNSFCFF TEAEKFLATD KVFCVGQLVC AVLADSEVQA KRAAKRVKIV YQDLEPLILT IEESIQHNSS FKPERKLEYG NVDE
Highest antigen sequence identity to orthologs:
- Mouse – 70%
- Rat – 70%
Target Information
AOX1 (Aldehyde oxidase 1) is a 1338 amino acid cytoplasmic protein that catalyzes oxidation of various aldehydes, producing hydrogen peroxide. Under certain conditions, AOX1 can catalyze formation of superoxide free radicals.
Defects in oxygen radical metabolism have been linked to amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder characterized by motor neuron death. AOX1 is highly expressed in the ventral horn of the spinal cord, and its gene is located in a chromosomal region implicated in ALS2, suggesting AOX1 as a candidate gene for ALS2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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