Thermo Fisher Scientific ZNF408 Polyclonal Antibody
Human ZNF408 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 1:50–1:200 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ZNF408. Recombinant protein control fragment (Product #RP-91666) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2650107 |
Product Specific Information
Immunogen sequence:
AAVAVVTEVE SAVQQEVASP GEDAAEPCID PGSQSPSGIQ AENMVSPGLK FPTQDRISKD SQPLGPLLQD GDVDEECPAQ AQMPPELQSN SATQQDPDGS GASFSSSARG TQPHGYLAKK LHSPSDQCPP RAKTPEPGAQ QSGFPTLSRS
Highest antigen sequence identity to the following orthologs:
- Mouse: 40%
- Rat: 25%
Target Information
Zinc-finger proteins contain DNA-binding domains and have diverse functions in transcriptional activation or repression. Most zinc-finger proteins include a Kruppel-type DNA binding domain and a KRAB domain, which interacts with KAP1 to recruit histone-modifying proteins.
ZNF408, a member of the Kruppel C2H2-type zinc-finger protein family, is encoded on human chromosome 11, which contains over 1,400 genes and represents nearly 4% of the human genome. Mutations in genes on chromosome 11 are associated with disorders such as Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema, and Smith-Lemli-Opitz syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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