Thermo Fisher Scientific HES6 Polyclonal Antibody
HES6 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 Immunocytochemistry에 적합. 인간과 랫드 시료에 반응하며, 고순도 Affinity chromatography 정제. PBS/glycerol buffer에 보관, -20°C에서 안정적 저장 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human HES6 (Accession Q96HZ4), corresponding to amino acid residues M1–K36 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852571 |
Product Specific Information
This antibody detects endogenous levels of total HES6.
Target Information
HES family members form complexes with TLE, the mammalian homologue of Groucho, mediated by the carboxy terminal WRPW motif. The HES/TLE complex binds directly to DNA to regulate transcription.
Most HES proteins, such as HES1 and HES5, preferentially bind to the N box (CACNAG), while HES2 binds both N and E box sites. HES6 does not bind DNA but inhibits HES1 activity, promoting transcription.
HES1 and HES2 are expressed in various adult and embryonic tissues, HES3 in cerebellar Purkinje cells, HES5 in the nervous system, and HES6 in the brain and developing limb buds.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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