Thermo Fisher Scientific ADAM23 Polyclonal Antibody
ADAM23 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot에 적합하며 인간과 생쥐 시료에 반응. ADAM23의 세포 접착 및 신경 관련 연구에 활용 가능. -20°C 보관, 1 mg/mL 농도.
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Applications and Tested Dilution
- Western Blot (WB): 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ADAM23 (Accession O75077), corresponding to amino acid residues A755–A805 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852905 |
Product Specific Information
This antibody detects endogenous levels of total ADAM23.
Target Information
ADAMs (a disintegrin and metalloproteinase domain), also known as MDCs (metalloproteinase, disintegrin, and cysteine-rich domain) or cellular disintegrins, are a family of proteins expressed in various tissues. They are involved in proteolysis, adhesion, fusion, and intracellular signaling.
ADAM23 is exclusively expressed in fetal and adult brain and may function as an integrin ligand in neural cells. Adhesion of neuroblastoma and astrocytoma cells is promoted by the disintegrin-like domain of ADAM23 and mediated by interaction with αvβ3 integrin. The metalloproteinase-like domain of ADAM23 lacks the typical catalytic residues, suggesting it primarily functions in cell adhesion rather than protease-mediated events. Evidence also indicates ADAM23 may act as a tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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