Thermo Fisher Scientific NRG3 Polyclonal Antibody
Human NRG3 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC에 사용 가능. 합성 펩타이드 항원을 기반으로 제작되었으며, 고순도 Affinity Chromatography 정제. PBS 및 sucrose buffer에 보관하며 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–1 µg/mL |
| Immunohistochemistry (IHC) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human NRG3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2608435 |
Product Specific Information
- Peptide sequence: TSINMQLPSR ETNPYFNSLE QKDLVGYSST RASSVPIIPS VGLEETCLQM
- Sequence homology: Cow: 93%; Dog: 86%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Target Information
This gene is a member of the neuregulin gene family, which encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4, both members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and induces cellular responses such as proliferation, migration, differentiation, and survival or apoptosis.
The NRG3 gene encodes neuregulin 3, which activates tyrosine phosphorylation of its cognate receptor ERBB4 and is thought to influence neuroblast proliferation, migration, and differentiation through ERBB4 signaling. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms; additional transcript variants have been described but their biological validity has not been verified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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