Thermo Fisher Scientific NRG3 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Peptide sequence: TSINMQLPSR ETNPYFNSLE QKDLVGYSST RASSVPIIPS VGLEETCLQM
• Sequence homology: Cow: 93%; Dog: 86%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Target Information

This gene is a member of the neuregulin gene family, which encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4, both members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and induces cellular responses such as proliferation, migration, differentiation, and survival or apoptosis.

The NRG3 gene encodes neuregulin 3, which activates tyrosine phosphorylation of its cognate receptor ERBB4 and is thought to influence neuroblast proliferation, migration, and differentiation through ERBB4 signaling. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms; additional transcript variants have been described but their biological validity has not been verified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.