Thermo Fisher Scientific Mouse G-CSF Recombinant Protein

Thermo Fisher Scientific Mouse G-CSF Recombinant Protein

Applications

• Western Blot (WB): Assay-dependent
• ELISA (ELISA): Assay-dependent
• Control (Ctrl): Assay-dependent

Product Specifications

Product Specific Information

Carrier-Free
Stock solutions can also be prepared at 50–100 µg/mL in appropriate sterile buffer. Carrier protein such as 0.2–1% BSA or HSA can be added when preparing the stock solution.

Target Information

G-CSF (Granulocyte colony stimulating factor) is a naturally occurring cytokine that stimulates the production and antibacterial function of neutrophils and monocytes.
Human G-CSF is an 18.8 kDa protein containing 175 amino acid residues, and a soluble isoform of the G-CSF receptor has been described.
The pleiotropic cytokine is produced by activated monocytes, macrophages, endothelial cells, fibroblasts, astrocytes, osteoblasts, and bone marrow cells.

G-CSF has specific effects on the proliferation, differentiation, and activation of hematopoietic cells. It is also expressed by various transformed cells such as carcinoma cells and myeloblastic leukemia cells.
G-CSF is encoded by two distinct DNA sequences, resulting in a full-size, high-activity and a shorter, low-activity isoform.
Highly conserved among species, G-CSF exerts its biological functions through interaction with its receptor expressed on hematopoietic progenitors, neutrophilic granulocytes, and certain carcinoma cell lines.

Clinical applications include treatment of neonatal infections, acute myocardial infarction, granulocyte transfusion in neutropenia patients, severe infections and sepsis, chronic autoimmune neutropenia, acute myeloid leukemia, Sweet’s syndrome, and AIDS.
G-CSF also serves as a marker protein for certain carcinomas such as bladder cancer, and dysfunction has been linked to Kostmann Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.