Thermo Fisher Scientific DES Monoclonal Antibody (OTI4G1), TrueMAB
Desmin 단백질을 인식하는 Mouse IgG1 단클론 항체로, WB, IHC, Flow Cytometry에 사용 가능. 인간 시료 반응성, 액상 형태, Affinity chromatography로 정제됨. 근육세포 특이적 단백질 연구용으로 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4G1 |
| Immunogen | Human fragment corresponding to amino acids 104–391 of human DES produced in E.coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.63 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, being predominantly expressed in all types of muscle cells (cardiac, skeletal, and smooth muscle). Its expression is regulated in a stage- and tissue-specific manner, induced during terminal development such as skeletal muscle cell differentiation.
In skeletal and cardiac muscle cells, desmin is localized in the Z-disk region and at the intercalated disk. Expression in smooth muscle is more heterogeneous.
Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue (e.g., rhabdomyosarcomas and leiomyosarcomas). During myocardial dysfunction, dramatic changes in desmin distribution have also been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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