Thermo Fisher Scientific CD4 VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1296)

Applications

Flow Cytometry (Flow)

• Tested Dilution: Assay-dependent

ELISA (ELISA)

• Tested Dilution: Assay-dependent

Surface Plasmon Resonance (SPR)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• Compatible with Direct ELISA

Target Information

The CD4 antigen is involved in the recognition of MHC class II molecules and acts as a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes (T helper cells), but may also be expressed by monocytes, macrophages, and dendritic cells.
At the tissue level, CD4 expression can be detected in thymus, lymph nodes, tonsils, spleen, and in specific regions of the brain, gut, and other non-lymphoid tissues.
CD4 functions to initiate or augment early T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase Lck. It may also mediate neuronal damage in infectious or immune-mediated diseases of the central nervous system.
Multiple alternatively spliced transcripts have been identified (RefSeq, July 2017).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.