Thermo Fisher Scientific MKL2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 170-300 of human MKL2 (NP_0547673) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MKL2,uniProtId:Q9ULH7-1,ncbiNodeId:9606,antigenRange:170-300,antigenLength:1088,antigenImageFileName:PA5-88993_MKL2_Q9ULH7-1_Rabbit.svg,antigenImageFileNamePDP:PA5-88993_MKL2_Q9ULH7-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

3.07 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2805280

Product Specific Information

Immunogen sequence: IIGVGKEDYP HTQGDFSFDE DSSDALSPDQ PASQESQGSA ASPSEPKVSE SPSPVTTNTP AQFASVSPTV PEFLKTPPTA DQPPPRPAAP VLPTNTVSSA KPGPALVKQS HPKNPNDKHR SKKCKDPKPR V; Positive Samples: LO2, Jurkat, Mouse pancreas; Cellular Location: Nucleus

Target Information

Serum response factor (SRF) is a transcription factor that binds the serum response element (SRE), a sequence that mediates the transient response of many cellular genes to growth stimulation. SRF regulates the transient response of several muscle genes in response to growth factors and recruits accessory myogenic factors to activate these muscle genes. SRF is required for the formation of vertebrate mesoderm leading to the origin of the cardiovascular system. Myocardin, in association with SRF in cardiac muscle cells, activates cardiac muscle promoters. Myocardin-related transcription factors A and B (MRTF-A and MRTF-B) interact with SRF and act as stimulators for its transcriptional activity. MRTF-B is crucial for skeletal myogenic differentiation.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.