Thermo Fisher Scientific NSD1 Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
FSDVHFDSKVK QSDPGKISEK GLSFENGKGP ELDSVMNSEN DELNGVNQVV PKKRWQRLNQ RRTKPRKRMN RFKEKENSEC

• Highest antigen sequence identity to the following orthologs:
  • Mouse: 80%
  • Rat: 72%

Target Information

This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region.
The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be further increased in the presence of other androgen receptor-associated coregulators.
This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator.

Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome.
One version of childhood acute myeloid leukemia is the result of a cryptic translocation with breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11.
Two transcript variants encoding distinct isoforms have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.