Thermo Fisher Scientific MAP4K3 Polyclonal Antibody
MAP4K3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, Flow cytometry에 적합. 고순도 Protein A 및 항원 친화 정제. 인간 반응성, 액상 형태로 장기 보관 시 -20°C 권장.
- 카탈로그번호
- PA526859
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein of human MAP4K3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2544359 |
Target Information
MAP4K3 (also known as GLK) is a member of the STE20 family of serine/threonine protein kinases and contains N-terminal catalytic and C-terminal regulatory domains. MAP4K3 acts upstream of MEKK1 and is stimulated by UV radiation and TNF-alpha, leading to activation of the JNK signaling pathway. It can directly activate PKC-T during TCR signaling. Enhanced MAP4K3 expression and activation of PKC-T and IKK have been observed in T cells of individuals with systemic lupus erythematosus. MAP4K3 functions as a pro-apoptotic kinase, orchestrating activation of BAX via modulation of PUMA, BAD, and BIM. The kinase activity can be stimulated by UV radiation and TNF-alpha, specifically activating the c-Jun N-terminal kinase (JNK) pathway. Formerly known as RAB8-interacting protein-like 1 (RAB8IPL1), MAP4K3 is now referred to as mitogen-activated protein kinase kinase kinase 3 (MAP4K3).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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