Thermo Fisher Scientific Human Factor XII Native Protein

Thermo Fisher Scientific Human Factor XII Native Protein

Applications

• Control (Ctrl): Assay-dependent

Product Specifications

Product Specific Information

RP-43076 contains native human Factor XII protein.
RP-43076 may be used as a positive control in many immunological assays.
The product is of human blood/plasma origin. Although the starting material was tested prior to initiation of the manufacturing process and found negative or nonreactive for anti-HIV-1/2, HIV-1 antigen(s), HBsAg, STS, anti-HCV, anti-HBcore, and anti-HTLV I & II, extreme caution should be used when handling this material as there is a margin of error in all tests.
This product is for in vitro research purposes only, and is not intended for clinical or diagnostic use.

Target Information

This single-chain zymogen is converted to a two-chain serine protease with a heavy chain (alpha-factor XIIa) and a light chain.
The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain, and a proline-rich domain, whereas the light chain contains only a catalytic domain.
Upon activation, further cleavages occur in the heavy chain, resulting in the production of beta-factor XIIa light chain and conversion of the alpha-factor XIIa light chain into the beta-factor XIIa heavy chain.
Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa.
Active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI.
Defects in this gene do not cause any clinical symptoms; the sole effect is prolonged whole-blood clotting time.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.