Thermo Fisher Scientific AKR1C3/DD3 Polyclonal Antibody
AKR1C3/DD3 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. Human 및 Rabbit 시료 반응성이 있으며, 단백질 A로 정제된 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rabbit |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human AKR1C3 (amino acids 161–270) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
AKR1C3 is a member of the aldo/keto reductase superfamily, consisting of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors.
AKR1C3 catalyzes the reduction of prostaglandin D2 (PGD2), PGH2, and phenanthrenequinone (PQ), as well as the oxidation of 9-alpha,11-beta-PGF2 to PGD2. It may play roles in allergic disease pathogenesis such as asthma and in the regulation of cell growth and differentiation.
This gene shares high sequence identity with three other gene members and is clustered with them at chromosome 10p15–p14.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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