Thermo Fisher Scientific MMP2 Monoclonal Antibody (VB3)

Applications and Tested Dilution

Product Specifications

Additional Formats

• Biotin Conjugate
• Request Custom Conjugation

Product Specific Information

MS804PABX targets MMP-2 in IF, IP, and WB applications and shows reactivity with Human samples.
The MS804PABX immunogen is recombinant Human pro-MMP-2 (native, 72 kDa).
MS804PABX detects MMP-2 which has a predicted molecular weight of approximately 62 kDa.

Target Information

Matrix metalloproteinases (MMPs) are proteolytic enzymes capable of degrading connective tissue components.
MMPs share a common activation mode and conserved amino acid sequence in the metal binding-active site region, and are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs).
MMPs and TIMPs play an important role in regulating angiogenesis.

MMP2 is synthesized as a 631 amino acid proenzyme activated by cleavage of the first 80 amino acids, containing propeptide, catalytic, and hemopexin domains.
The MMP family includes at least eighteen secreted and membrane-bound zinc endopeptidases that collectively degrade extracellular matrix components such as collagens, fibronectin, laminin, and basement membrane glycoproteins.

Functionally, MMP2 is involved in tissue remodeling.
Mutations in the MMP-2 gene are associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome.
Two transcript variants encoding different isoforms of MMP-2 have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.