Thermo Fisher Scientific KChIP3 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Peptide sequence:
STVRHQPEGL DQLQAQTKFT KKELQSLYRG FKNECPTGLV DEDTFKLIYA

Sequence homology:
Cow: 100%
Dog: 100%
Guinea Pig: 92%
Horse: 100%
Human: 100%
Mouse: 100%
Pig: 100%
Rabbit: 100%
Rat: 100%
Zebrafish: 92%

Target Information

Voltage-gated potassium (Kv) channels are key components of the potassium currents in the heart and central nervous system. In the heart, Kv4 channels are involved in the repolarization phase of the action potential. In the brain, these channels prevent reverse-propagation of action potentials.

Associated with Kv4 channels are calcium-binding proteins termed KChIPs (Kv channel interacting proteins), which bind to the cytoplasmic amino termini of Kv4 alpha-subunits and modulate their function.
There are three known KChIPs:

• KChIP1: Expressed in the brain
• KChIP2: Expressed in brain, heart, and lung (three isoforms: a, b, c)
• KChIP3: Also known as calsenilin and DREAM, expressed in brain and testis

KChIP3 binds to regulatory DRE and represses transcription from the early-response gene c-fos, functioning as a DNA-binding transcriptional regulator. It also associates with presenilins and is implicated in beta-amyloid formation.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.