Thermo Fisher Scientific Human Lyn Isoform B, His Tag Recombinant Protein

Applications

Tested Dilution

Publications

Kinase Assay (KA)

Assay-dependent

-

Product Specifications

Species

Human

Expression System

Baculovirus

Amino acid sequence

Full length

Tag

His-tag

Molecular weight

57.4 kDa

Class

Recombinant

Type

Protein

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

purified

Storage buffer

50mM tris, pH 7.5, with 0.05% NP-40, 1mM DTT, 50% glycerol, 0.05mM EDTA, 100mM NaCl

Contains

no preservative

Storage conditions

-80° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Dry ice

Product Specific Information

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.

Protein Form: Full Length

Target Information

LYN is a SRC family kinase expressed predominantly in hematopoietic cells. Activation of LYN has been shown to lead to imatinib resistance in CML patients. LYNB and the slightly shorter LYNA are the two isoforms of LYN. Diseases associated with LYN include Sarcoma and Myeloid Leukemia. Among its related pathways are Signaling by Erythropoietin and Regulation of actin dynamics for phagocytic cup formation. Gene Ontology (GO) annotations related to Lyn Isoform B include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of Lyn Isoform B is HCK.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.