Thermo Fisher Scientific KIT Monoclonal Antibody (OTI1E2), TrueMAB

Applications

• Luminex (LUM): Assay-dependent

Product Specifications

Target Information

KIT (c-KIT) is a proto-oncogene and a type 3 transmembrane receptor for mast cell growth factor (MGF, also known as stem cell factor). KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. Together with its ligand, KIT regulates the growth and activation of various hematopoietic and non-hematopoietic cells.

Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Deregulation of KIT receptor tyrosine kinase (TK), particularly the D816V mutation, is a therapeutic target for neoplastic mast cell growth.

c-Kit is expressed in hematopoietic stem cells, germ cells, mast cells, and gastrointestinal tract Cajal cells. Upon binding of its ligand stem cell factor (SCF), c-Kit dimerizes, leading to receptor activation and autophosphorylation of tyrosine residues such as Tyr703. This enables Grb2 docking and activation of the Ras/ERK signaling pathway. SCF/c-Kit can activate multiple downstream signaling pathways including PI3K, PLC-γ, and JAK/STAT. Activation of the c-Kit receptor is essential for hematopoiesis, stem cell maintenance, and gametogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.