Thermo Fisher Scientific SEPN1 Polyclonal Antibody
Human SEPN1 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 1:25~1:100 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS(pH 7.4)와 40% glycerol에 보관. SEPN1 관련 근육 질환 연구에 적합.
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:25–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region derived from internal residues of human selenoprotein N, 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2636204 |
Product Specific Information
This antibody detects endogenous levels of total SEPN1 protein.
Target Information
SEPN1 is a selenoprotein containing a selenocysteine (Sec) residue at its active site. Mutations in the SEPN1 gene cause classical multiminicore disease and congenital muscular dystrophy with spinal rigidity and restrictive respiratory syndrome.
The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3′ UTR of selenoprotein genes contains a stem-loop structure called the SECIS element, necessary for recognizing UGA as a Sec codon rather than a stop signal.
Two alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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