Thermo Fisher Scientific GUCY1B3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:200–1:2,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
MYGFVNHALE LLVIRNYGPE VWEDIKKEAQ LDEEGQFLVR IIYDDSKTYD LVAAASKVLN LNAGEILQMF GKMFFVFCQE SGYDTILRVL GSNVREFLQN LDALHDHLAT IYPGMRAPSF RCTDAEKGKG LILHYYSERE GLQDIVIGII KTVAQQIHGT EIDMKVIQQR NEECDHTQFL IEEKESKEED FYEDLDRFEE NGTQESRISP YTFCKAFPFH IIFDRDLVVT QCGNAIYRVL PQLQPGNCSL

Target Information

Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase: a soluble form (GCS or sGC), which acts as a receptor for nitric oxide, and a membrane-bound receptor form (GC), which acts as a peptide hormone receptor.
GC-C protein consists of an extracellular domain, a single transmembrane domain, and a cytoplasmic region with kinase-like and catalytic domains. It exists as two glycosylated forms: a 130 kDa precursor in the endoplasmic reticulum and a 145 kDa form on the plasma membrane.
Ligand binding to GC-C promotes cGMP accumulation. GC-C acts as the receptor for heat-stable enterotoxins from pathogenic E. coli causing secretory diarrhea, and also binds guanylin and uroguanylin peptides regulating renal function.

⚠ WARNING: This product can expose you to chemicals including mercury, known to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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