Thermo Fisher Scientific APBA3 Polyclonal Antibody

Applications

Immunoprecipitation (IP)

• Tested Dilution: 8–15 µL/mg of lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt.

Target Information

The munc-18 interacting protein (Mint) family consists of evolutionarily conserved adaptor proteins involved in membrane transport and organization. In mammals, three isoforms exist: Mint1, Mint2, and Mint3.

• The C-terminal half of these proteins is highly conserved and contains PTB and PDZ domains that mediate protein interactions.
• Mint1 and Mint2 are brain-specific and bind to Munc18, a key component of synaptic vesicle fusion.
• Mint3 is ubiquitously expressed, at the lowest levels in brain and testis, and does not interact with Munc18.
• Mint3 interacts with the Alzheimer’s disease-related amyloid precursor protein (APP) via its PTB and PDZ domains, potentially linking APP to transport machinery components that regulate its trafficking, endocytosis, and metabolism.
• Abnormal APP metabolism is implicated in early-onset Alzheimer’s disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.