Thermo Fisher Scientific Bestrophin Polyclonal Antibody, FITC
FITC 결합형 Bestrophin 폴리클로날 항체로 시각세포 연구에 적합. Western blot, ELISA, IP 등 다양한 응용 가능. Dog, Human, Non-human primate 반응성. 고순도 Affinity chromatography 정제 및 안정적 액상 형태. -20°C 암소 보관.
- 카탈로그번호
- CBEST-FITC
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide taken within amino acid region 530–580 on canine Bestrophin 1 protein |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The retinal pigment epithelium (RPE) and choroid represent a differentiated system of the eye that sustains normal retinal health and function. Best vitelliform macular dystrophy (Best disease) is an early-onset autosomal dominant condition characterized by accumulation of lipofuscin-like material within and beneath the RPE, leading to progressive central vision loss. This material appears as a yellow mass that becomes darker and irregular over time, known as “scrambling the egg.”
Best disease often results from mutations in the Bestrophin gene, which encodes a protein with four transmembrane domains localized to the basolateral plasma membrane of RPE cells. Human Bestrophin forms oligomeric chloride channels sensitive to intracellular calcium. Missense mutations can reduce or abolish Bestrophin-mediated membrane current. The human Bestrophin gene encodes a 585 amino acid protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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