Thermo Fisher Scientific LMNA Monoclonal Antibody (OTI1B7), TrueMAB
인간 LMNA 단백질을 인식하는 Mouse IgG1 단일클론 항체로 Western Blot에 최적화되어 있습니다. HEK293T 세포에서 발현된 재조합 LMNA 단백질을 면역원으로 사용하였으며, 1 mg/mL 농도의 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
- Western Blot (WB): 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B7 |
| Immunogen | Full length human recombinant protein of human LMNA produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic side of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished: A-type lamins and B-type lamins.
A-type lamins include lamin A, lamin C, and lamin Adel10, which arise from the same gene by alternative splicing.
B-type lamins include lamin B1 and lamin B2, derived from distinct genes.
Mutations in A-type lamins are associated with rare but dominant genetic disorders such as:
- Emery-Dreifuss muscular dystrophy
- Dilated cardiomyopathy with conduction-system disease
- Dunnigan-type familial partial lipodystrophy
Expression of A-type lamins correlates with cell differentiation and chromatin interaction, suggesting a role in the regulation of differential gene expression.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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