Thermo Fisher Scientific Transferrin receptor Polyclonal Antibody
Rabbit polyclonal antibody targeting human Transferrin receptor (CD71). Validated for WB and IHC applications. Lyophilized, unconjugated form for research use only. Essential for studies of iron metabolism and erythropoiesis.
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- OST00288W-100UL
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- pk
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Thermo Fisher Scientific Transferrin Receptor Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:2,000 |
| Immunohistochemistry (IHC) | 1:300–1:2,000 |
| Miscellaneous PubMed (Misc) | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the N-terminal region of human Transferrin receptor protein 1 (CD71) conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: Transferrin receptor.
Target Information
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is recycled to the cell surface, returning to neutral pH and losing affinity for apotransferrin.
Transferrin receptor is essential for erythrocyte and nervous system development. Serum transferrin receptor (sTfR) is used to detect erythropoietin (EPO) misuse and as a diagnostic marker for various anemias, including those associated with rheumatoid arthritis, pregnancy, irritable bowel syndrome, and HIV.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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