Thermo Fisher Scientific ASAP1 Polyclonal Antibody
ASAP1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot, IHC, ICC/IF 등 다양한 응용에 적합. 인간, 마우스, 랫트 반응성. 고순도 친화 크로마토그래피 정제. 연구용 전용 제품.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ASAP1 (Accession Q9ULH1), corresponding to amino acid residues K508–S558 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2899518 |
Product Specific Information
Antibody detects endogenous levels of total ASAP1 antibody.
Target Information
ASAP1, also known as Development and differentiation enhancing factor 1, is a protein with two ANK repeats, an Arf-GAP domain, a PH domain, and a SH3 domain.
ASAP1 is a homodimer known to interact with SRC and CRK, and its activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2).
It possesses PIP2-dependent GTPase-activating protein activity for ARF1 and ARF5, and lesser activity towards ARF6.
ASAP1 may coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2.
It may also function as a signal transduction protein involved in fibroblast differentiation into adipocytes and other cell types.
Widely expressed in most tissues, ASAP1 is a proto-oncogene involved in invasive breast cancer and other malignant tumors such as uveal melanomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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