Thermo Fisher Scientific Human LGI4 Synthetic Peptide

Thermo Fisher Scientific Human LGI4 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 14 amino acids near the center of human LGI4.
PEP-0635 can be used as a blocking peptide with polyclonal antibody PA5-20515.

Target Information

The leucine-rich, glioma inactivated gene 4 (LGI4) is a member of the LGI family in which LGI1 is the exemplar.
The LGI family consists of four highly related proteins containing leucine-rich repeats (LRRs), similar to other transmembrane signaling molecules and receptors.

LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), characterized by focal seizures with auditory symptoms.
Although LGI4 shares high homology and expression pattern with LGI1, mutations in LGI4 have not been associated with ADTLE.
LGI4 is located in a region linked to benign familial infantile convulsions, and a GC-to-AT polymorphism has been correlated with childhood absence epilepsy.

Decreased LGI4 expression in cultured cells inhibits myelination, suggesting its role in neural development.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.