Thermo Fisher Scientific SLAMF7 Monoclonal Antibody (OTI1F1), TrueMAB
인간 SLAMF7 단백질을 인식하는 Mouse IgG1 단일클론 항체로, WB, IHC, Flow Cytometry 등에 사용 가능. Affinity chromatography로 정제된 액상형 항체이며, 고농도(1 mg/mL)로 제공. 연구용으로 NK세포 활성 및 림프구 부착 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Flow Cytometry (Flow) | Assay-Dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1F1 |
| Immunogen | Full length human recombinant protein of SLAMF7 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
SLAMF7 contains one Ig-like C2-type (immunoglobulin-like) domain.
Isoform 1 mediates NK cell activation through a SAP-independent, ERK-mediated pathway and may play a role in lymphocyte adhesion.
Isoform 3 does not mediate activation. SAP can bind the cytoplasmic tail of isoform 1 when phosphorylated in the presence of Fyn (in vitro).
SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung, and trachea.
Expression is detected in NK cells, activated B-cells, and NK-cell lines, but not in promyelocytic, B-, or T-cell lines.
Isoform 3 is expressed at a much lower level than isoform 1. Three named isoforms are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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