Thermo Fisher Scientific IFN gamma VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1294)

Applications

• ELISA (Assay-dependent)

Product Specifications

Product Specific Information

• Compatible with Direct ELISA

Target Information

IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor and immune interferon produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemagglutinin, and other cytokines.
It is a dimeric glycoprotein consisting of two 146 amino acid subunits (~45 kDa). On SDS-PAGE, IFN gamma appears as 25, 20, and minor 15.5 kDa bands due to differential glycosylation.
The biological activity of IFN gamma homodimer is highly species-specific; human IFN gamma does not cross-react with mouse.
Functions include antiviral activity, tumor antiproliferative activity, induction of MHC class I and II, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes.
Activation occurs via binding to IFN gamma receptor I and II, initiating the JAK-STAT pathway.
Human IFN gamma shows ~40% sequence homology with mouse IFN gamma and is upregulated by IL2, FGF basic, EGF, and downregulated by vitamin D3 or DMN.
Gene mutations are associated with aplastic anemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.