Thermo Fisher Scientific PDGFRB Monoclonal Antibody (OTI3B5), TrueMAB
인간 PDGFRB 단백질을 인식하는 마우스 단클론 항체로, Western blot과 Immunocytochemistry에 적합합니다. 고순도의 액상 형태로 제공되며, 1 mg/mL 농도에서 PBS, BSA, 글리세롤 완충액에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:4,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3B5 |
| Immunogen | Full length human recombinant protein of human PDGFRB produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
PDGFRB is a receptor tyrosine kinase implicated in atherogenesis and in cell transformation by the SIS oncogene. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer composed of both platelet-derived growth factor receptor alpha and beta polypeptides.
The gene is located on chromosome 5, flanked by genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor, which may be implicated in the 5-q syndrome.
A translocation between chromosomes 5 and 12, fusing PDGFRB (CD140b) with the ETV6 leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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