Thermo Fisher Scientific TACR3 Polyclonal Antibody
Human TACR3 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 등 연구용에 적합. 항원 친화 크로마토그래피로 정제된 액상 형태이며, 1 mg/mL 농도. 인간 및 유인원 종에 높은 교차 반응성을 보임. 연구용 한정 제품.
- 카탈로그번호
- PA534249
- 판매단위
- pk
카탈로그
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested at 20 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 17 amino acid peptide from C-terminal cytoplasmic domain of human TACR3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551601 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human, Gorilla, Monkey (100%)
- Gibbon, Marmoset (94%)
- Mouse, Rat, Hamster, Panda, Bovine, Dog, Rabbit (88%)
Target Information
The tachykinins are a family of small peptides that include the neurotransmitters substance P, neurokinin A, and neurokinin B. These act on three distinct seven-transmembrane G-protein coupled receptors at different concentrations.
The NK-3 receptor (NK3R) has greatest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Upon ligand binding, NK3R activates a phosphatidylinositol-calcium second messenger system, likely leading to the release of vasopressin and oxytocin.
NK3R may play roles in learning and memory, as mice lacking this gene show cognitive deficits. Although suggested to regulate vagal afferent relay neurons, these receptors are likely activated by substance P or neurokinin A, since airway nerves do not express neurokinin B.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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