Thermo Fisher Scientific COMMD1 Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MAAGELEGGK PLSGLLNALA QDTFHGYPGI TEELLRSQLY PEVPPEEFRP FLAKMRGILK SIASADMDFN QLEAFLTAQT KKQGGITSDQ AAVISKFWKS HKTKIRESLM NQSRWNSGLR GLSWRVDGKS QSRHSAQIHT PVAIIELELG KYGQESEFLC LEFDEVKVNQ ILKTLSEVEE SISTLISQPN

Target Information

Proposed scaffold protein implicated in diverse physiological processes, potentially linked to regulation of ubiquitination of specific cellular proteins.

• Modulates cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1.
• Promotes ubiquitination and degradation of NF-κB subunit RELA, down-regulating NF-κB activity.
• Regulates membrane expression and ubiquitination of SLC12A2 and ENaC subunits.
• Promotes localization of SCNN1D to recycling endosomes and CFTR surface expression.
• Involved in copper ion homeostasis and ATP7A trafficking within hepatocytes.
• Binds one copper ion per monomer and associates with CCC and WASH complexes.
• Participates in regulation of HIF1A-mediated transcription by competing with ARNT/Hif-1β.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.