Thermo Fisher Scientific PGP9.5/UchL1 (pan-Neuronal Marker) Monoclonal Antibody (31A3)
PGP9.5/UchL1 단백질을 인식하는 신경세포 특이적 단클론 항체입니다. Western blot, IHC, ICC, Flow Cytometry 등 다양한 응용에 사용 가능합니다. 여러 종에 반응하며, 신경세포 및 신경퇴행성 질환 연구에 적합합니다.
- 카탈로그번호
- 7345-MSM1-P1ABX
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Bovine, Dog, Human, Mouse, Pig, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 31A3 |
| Immunogen | Native UchL1 (PGP9.5) protein from brain |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
PGP9.5 (Protein gene product 9.5, also known as UCH-L1 or PARK5) is a neuron-specific protein distinct from neuron-specific enolase. It has a molecular weight of approximately 27 kDa and belongs to the ubiquitin carboxyl-terminal hydrolase family (peptidase family C12). PGP9.5 exhibits both ubiquitin hydrolase and ligase activities, generating ubiquitin monomers by hydrolyzing small C-terminal adducts of ubiquitin.
This protein is expressed in neurons and nerve fibers throughout the central and peripheral nervous systems, as well as in neuroendocrine cells, renal tubules, spermatogonia, Leydig cells, ova, and corpus luteum cells. Overexpression of PGP9.5 is associated with non-small cell lung cancer, while decreased expression is linked to Huntington’s and Alzheimer’s diseases. Due to its presence in neuronal inclusions, PGP9.5 serves as a valuable pan-neuronal marker and is useful in studies of neurodegenerative disorders such as Parkinson’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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