Thermo Fisher Scientific PGP9.5/UchL1 (pan-Neuronal Marker) Monoclonal Antibody (31A3)

Applications and Tested Dilution

Product Specifications

Target Information

PGP9.5 (Protein gene product 9.5, also known as UCH-L1 or PARK5) is a neuron-specific protein distinct from neuron-specific enolase. It has a molecular weight of approximately 27 kDa and belongs to the ubiquitin carboxyl-terminal hydrolase family (peptidase family C12). PGP9.5 exhibits both ubiquitin hydrolase and ligase activities, generating ubiquitin monomers by hydrolyzing small C-terminal adducts of ubiquitin.

This protein is expressed in neurons and nerve fibers throughout the central and peripheral nervous systems, as well as in neuroendocrine cells, renal tubules, spermatogonia, Leydig cells, ova, and corpus luteum cells. Overexpression of PGP9.5 is associated with non-small cell lung cancer, while decreased expression is linked to Huntington’s and Alzheimer’s diseases. Due to its presence in neuronal inclusions, PGP9.5 serves as a valuable pan-neuronal marker and is useful in studies of neurodegenerative disorders such as Parkinson’s disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.