Thermo Fisher Scientific CD54/ICAM-1 Recombinant Rabbit Monoclonal Antibody (ICAM1/8677R)
Recombinant rabbit monoclonal antibody targeting human ICAM-1 (CD54). Validated for IHC (Paraffin) applications. High specificity and purity via Protein A/G purification. Suitable for research use in inflammation and cell adhesion studies.
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2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD54/ICAM-1 Recombinant Rabbit Monoclonal Antibody (ICAM1/8677R)
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ICAM1/8677R |
| Immunogen | Recombinant fragment raised against intracellular epitope of human ICAM1 (exact sequence is proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: HeLa or SW480 cells, Human tonsil, Raji
- Cellular Location: Cell surface
Target Information
ICAM-1 (CD54) is an 85–110 kDa single-chain type I integral membrane glycoprotein composed of an extracellular domain with five immunoglobulin superfamily repeats, a transmembrane region, and a cytoplasmic domain.
It has seven potential N-linked glycosylation sites and shares significant amino acid sequence homology with ICAM-2 (CD102) and ICAM-3 (CD50).
ICAM-1 binds integrins such as CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1), and also serves as a receptor for Rhinovirus.
It is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B and T lymphocytes (low levels), monocytes, macrophages, dendritic cells, and neutrophils. Expression increases during inflammation and is also observed in some carcinoma and melanoma cells.
Soluble ICAM-1 can be found in plasma and is elevated in various inflammatory syndromes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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