Thermo Fisher Scientific TMC6 Polyclonal Antibody
Human TMC6 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:50–1:200 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보존. 피부 질환 관련 TMC6 연구용으로 적합.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TMC6 (Product #RP-101332) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856746 |
Product Specific Information
Immunogen sequence:
YYNRTVQLRC RSSRPLLGNF VRSAWPSLRL YDLELDPTAL EEEEKQSLLV KELQSLAVAQ RDHMLRGMPL SLAEKRSLRE KSRT
Target Information
TMC6 interacts with and forms a complex with the zinc transporter 1 (SLC30A1), localizing to the endoplasmic reticulum, nuclear membrane, and Golgi apparatus.
Inactivation of the TMC6 gene is implicated in epidermodysplasia verruciformis (EV), an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin.
EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3.
TMC6 encodes integral membrane proteins predicted to form transmembrane channels, with 10 transmembrane domains and 2 leucine zipper motifs.
Diseases associated with TMC6 include Epidermodysplasia Verruciformis and Superficial Mycosis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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