Thermo Fisher Scientific CRMP3 Polyclonal Antibody
CRMP3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, ELISA, IP에 적합합니다. Mouse CRMP3의 509-527 아미노산 서열을 면역원으로 사용하며, 다양한 종에 반응합니다. 액상 형태로 -20°C 보관이 권장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Cat, Human, Mouse, Non-human primate, Pig, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 509–527 of Mouse CRMP3. The peptide was covalently modified to achieve desired antigenicity before coupling to carrier protein. Sequence: PAKPGSGTQARASCSGKIS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | −20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Collapsin response mediator proteins (CRMPs), including CRMP-1 (DRP-1), CRMP-2 (DRP-2 or TOAD64), CRMP-3 (DRP-4), CRMP-4 (DRP-3) and CRMP-5 (DRP-5), mediate signal transduction after exposure of neural cells to the axon guidance molecule Semaphorin 3A (SEMA3A)/collapsin.
CRMPs are present in the developing cerebral cortex and neocortical neurons and are responsive to SEMA3A. In the adult brain, the expression of CRMPs is dramatically downregulated; however, they remain expressed in structures that retain their capacity for differentiation and plasticity.
CRMP-3 is expressed transiently in developing spinal cord and selectively in the postnatal cerebellum.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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