Thermo Fisher Scientific PITX2 Polyclonal Antibody, MaxPab

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

-

in situ PLA (PLA)

1:1200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PITX2 (NP_700476.1, 1 a.a. approximately 271 a.a) full-length human protein.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: METNCRKLVS ACVQLEKDKS QQGKNEDVGA EDPSKKKRQR RQRTHFTSQQ LQELEATFQR NRYPDMSTRE EIAVWTNLTE ARVRVWFKNR RAKWRKRERN QQAELCKNGF GPQFNGLMQP YDDMYPGYSY NNWAAKGLTS ASLSTKSFPF FNSMNVNPLS SQSMFSPPNS ISSMSMSSSM VPSAVTGVPG SSLNSLNNLN NLSSPSLNSA VPTPACPYAP PTPPYVYRDT CNSSLASLRL KAKQHSSFGY ASVQNPASNL SACQYAVDRP V

Target Information

Pilx2 is a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. It plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this protein are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.