Thermo Fisher Scientific CDKL5 Recombinant Rabbit Monoclonal Antibody (1H57L44)
CDKL5 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot 및 면역세포염색에 적합합니다. 인간, 생쥐, 랫트 반응성이 있으며, Expi293 시스템에서 발현되었습니다. 단백질 A로 정제된 액상 항체로 4°C 보관 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 1H57L44 |
| Immunogen | Protein corresponding to human CDKL5 [aa636–aa774] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2866472 |
Product Specific Information
This antibody is predicted to react with Bovine.
Target Information
CDKL5 serine/threonine kinase (STK9) is associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome and Rett syndrome (RTT). CDKL5 regulates nuclear speckle morphology by controlling the phosphorylation state of splicing regulatory proteins, and may indirectly influence pre-mRNA processing by modulating splicing factor dynamics. Mutations in CDKL5 are a major cause of infantile spasms and early epileptic seizures in female patients, as well as later intractable seizure disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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