Thermo Fisher Scientific KCNK16 Polyclonal Antibody
KCNK16 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot과 IHC에 적합합니다. TALK-1 채널 연구용으로 설계되었으며, 인간 시료에 반응합니다. 동결건조 형태로 제공되며, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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- OSK00049W-100UL
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 10–60 of human KCNK16 conjugated to an immunogenic carrier protein. Target family: TALK-1 (UniProt ID: Q96T55-1). |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The antigen shares about 95% identity with rat and mouse sequences.
- Specificity: KCNK16.
Target Information
The KCNK16 gene encodes the TALK-1 channel, an abundant K⁺ channel transcript found in mouse and human beta-cells.
There are four human TALK-1 transcript variants, including two functional forms (TALK-1a and TALK-1b).
The TALK-1 structure includes four transmembrane domains, two extracellular loops, and intracellular N- and C-termini.
- The C-terminal tail influences the magnitude of channel activation.
- The N-terminus is important for protein interactions.
TALK-1 (two-pore domain K⁺ channel, K2p 16.1) modulates glucose-stimulated insulin secretion dependent on beta-cell Ca²⁺ influx.
It produces outwardly rectifying, non-inactivating K⁺ currents enhanced by elevated extracellular pH.
The channel is pH-sensitive and activated by singlet oxygen and nitric oxide.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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