Thermo Fisher Scientific CD16/FcgammaReceptor III Monoclonal Antibody (HuNK2)
Thermo Fisher Scientific의 CD16/FcgammaReceptor III 단클론 항체(HuNK2)는 인간 NK 세포 인식용으로 개발된 Mouse IgG2a 항체입니다. ICC/IF, Flow Cytometry, Functional Assay에 적합하며, Protein A/G 정제 및 PBS 기반 보존액으로 제공됩니다. 연구용 전용 제품입니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
| Functional Assay (Functional) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HuNK2 |
| Immunogen | Human peripheral blood lymphocytes from a NK-leukemia patient |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD16 encodes a receptor that recognizes the Fc portion of immunoglobulin G and is involved in the clearance of immune complexes from the circulation, as well as other functions such as cellular mediated cytotoxicity and enhancement of virus infections.
This gene, FCGR3A, shares a high degree of similarity with another nearby gene, FCGR3B, located on chromosome 1.
The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, while FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage.
Mutations in this gene have been associated with immunodeficiency 20 and have been linked to susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Diseases associated with FCGR3A include Immunodeficiency 20 and Herpes Zoster.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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