ELK Biotechnology CE104 rabbit pAb

ELK Biotechnology CE104 rabbit pAb

제품 개요

CE104 rabbit pAb는 인간 CE104 단백질(AA 415-465) 유래 합성 펩타이드로 면역화된 폴리클로날 항체입니다. 세포 중심체 및 섬모 구조 연구에 적합하며, 웨스턴 블롯(WB) 분석에 사용됩니다.

제품 정보

세포 내 위치

Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
In interphase non-ciliated cells, localizes to the distal ends of both the mother and daughter centrioles.
In ciliated cells, present at the distal end of the daughter centriole and at the tip of primary cilium.
Localization at the ciliary tip is also observed in motile cilia.
Throughout S phase, associated with both mother and daughter centrioles in each centrosome.
During metaphase and telophase, present at both spindle poles.

Background

This gene encodes a centrosomal protein required for ciliogenesis and for ciliary tip structural integrity. The mammalian protein contains three amino-terminal hydrophobic domains, two glycosylation sites, four cysteine-rich motifs, and two regions with homology to the glutamate receptor ionotropic, NMDA 1 protein.
During ciliogenesis, the encoded protein translocates from the distal tips of the centrioles to the tip of the elongating cilium.
Knockdown of the protein in human retinal pigment cells results in severe defects in ciliogenesis with structural deformities at the ciliary tips.
Allelic variants of this gene are associated with the autosomal-recessive disorder Joubert syndrome, which is characterized by a distinctive mid-hindbrain and cerebellar malformation, oculomotor apraxia, irregular breathing, developmental delay, and ataxia.
[provided by RefSeq, Feb 2016]